Long-term medication should pay attention, beware of drug-induced liver damage!
2022-08-07: [Article Link]
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Visiting expert Xu Xiao Yuan, Director of the Infection Unit, Beijing University Hospital No. 1
The liver is known as a 24-hour “chemical treatment plant”, which carries on day-to-day metabolism and detoxification of the body, helps to maintain the normal functioning of the entire body and ensures that the metabolism is normal.
However, it is inevitable that people are ill, of which medication is the most common form of treatment, that most drugs are metabolized through the liver, and that in some special cases there are other “pathological” risks associated with the drug “repairing the disease”, which is the pharmaceutical liver injury, which is the most common drug side effect.
Launch of the “Starfire Project — pharmacopathic hepatitis normative treatment of 100 counties” project
With a view to improving the implementation of the “Healthy China 2030” programme, and in response to the relevant provisions of the State Council to promote the construction of a system of level-level consultations, the project “Sarbing Project — Quantities for the Normalization of Drug Hepatic Diseases”, co-sponsored by the Technical Committee for the Prevention and Control of Drug Hepatitis Damage of the China Medical Biotechnology Association and the Hepatic Diseases Division of the Chinese Medical Association, and supported by the Beijing Association and Pharmacy Plants Ltd., has recently been launched, with the aim of focusing on the normative and clinical treatment of diseases, further exploring and summarizing the country's clinical experience with pharmacological hepatitis, improving the dissemination and dissemination of knowledge of the disease among grass-roots medical workers, promoting the exchange of standard medical treatments for pharmacological hepatitis and upgrading the capacity of grass-roots clinical practitioners. Drug liver injuries are not easily detected.
Professor Xu Xiao Yuan, Director of the Infection Section, Beijing University Hospital No. 1
Professor Xu Xiao Yuan, Director of the Infection Section at Beijing University Hospital No. 1, stated that pharmacological liver injuries can be classified as acute (within six months) and chronic (over six months), with chronic pharmacological liver injuries being less easily detected.
1. Acute pharmaceutical liver damage
A serious person can cause acute or subacute liver failure or even death.
During acute liver injuries, non-specific symptoms can be observed in some patients, such as fatigue, stomach failure, nausea, vomiting, skin, yellow eyes, increased urinal colour, etc.
There may also be cases of co-inflicted rashes and fever.
2. Chronic pharmaceutical liver damage
If the liver damage of the patient continues for more than six months, this means that the liver damage may be transformed into a chronic or longer recovery.
Chronic pharmaceutical liver injuries are usually associated with long-term use of certain drugs, clinically manifested as chronic, repeated mild increases in liver enzyme, and most patients may have no apparent symptoms.
A further part of the chronic drug liver injury was transformed by the chronicisation of an acute liver injury event, for which liver damage for more than 6 to 12 months was still not fully normal, and for which acute liver damage may be accompanied by corresponding non-specific symptoms, but may not be visible. As a result, chronic drug liver injuries are more clinically hidden and less easily detected and diagnosed.
Two types of drugs are easy to cause pharmacological liver damage.
Professor Mao Weimin, Head of the Irrigation Unit of the Benevolence Hospital, Faculty of Medicine, Shanghai Transport University
“China is rapidly entering an ageing society, and the elderly population is often associated with a variety of slow diseases requiring multiple medications, which increases the risk of drug-related liver damage. Moreover, in the country, public awareness and awareness of safe and rational drug use are generally weak, so that the prevention and treatment of drug-related liver damage is an issue that cannot be ignored in China. According to studies, in our country, drugs that are prone to liver damage:
1. Health products and traditional medicines
Health-care products are generally considered by the public to be useful and harmless, and Chinese medicines are often considered to be less reactive, so that, in the event of clinical liver damage, few patients voluntarily report to a doctor the history of application of health-care products and Chinese medicines, leading to underestimation or even neglect of liver injuries caused by health-care products and Chinese medicines. 2. Chemical substances, biological agents, etc.
Of these, anti-tuberculosis, anti-cancer or immunostatic regulators, antibiotics, etc. are the most common.
The fourth group is a high-life population with pharmacological liver damage.
1. Older persons with chronic illnesses requiring long-term medication
Professor Xu Xiao Yuan cautioned that older persons with chronic diseases may be treated with multiple medications at the same time, and that with age, liver metabolism is slow, the time spent in blood with drugs increases and the risk of pharmacological liver damage is of particular concern.
Children's liver growth is not yet fully mature, and the risk of liver damage is proportionately higher if there is an unreasonable use of drugs.
According to Professor Mao Weimin, research has shown that women may show higher susceptibility to certain drugs, such as Minotal and Medoba, and a higher risk of substance-related liver damage.
4. History of past liver diseases